Although recent reviews have failed to provide evidence of the efficacy of several oral and topical complementary therapies for rheumatoid arthritis (RA), a group of researchers in Japan decided to use high voltage alternating current (HVAC) for chronic inflammatory autoimmune diseases because the method is mainly used in patients with headaches, stiff shoulders, chronic constipation, and insomnia in whom conventional therapy is ineffective.
For their randomized, double-blind, sham surgery-controlled study published in the July 2013 edition of the journal Clinical Biochemistry and Nutrition, Yuji Naito, MD, of Kyoto Prefectural University, and colleagues treated 24 patients who met U.S. criteria for active RA diagnosis by the College of Rheumatology using either hyperbaric therapy or sham therapy offered through medical device manufacturer Cocoroca Corp.’s Legacis Plus System for 12 weeks, and then observed these patients for 4 weeks after treatment.
At baseline, four weeks, eight weeks, 12 weeks, and 16 weeks, the researchers calculated and compared patients’ 28 joint disease activity scores based on C-reactive protein (DAS28-CRP), visual pain analogues score (VAS), joint swelling, joint compression pain, modified health assessment questionnaire responses for arthritis function, and “changes in biomarker laboratory indicators: erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), matrix metalloproteinase 3 (MMP-3), and CRP.”
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